An aqueous composition is described herein that is safe, convenient, and effective for cleansing dental appliances. The primary cleansing agent in this composition is a surfactant, which allows for fast and effective cleaning without damaging or discoloring the plastic of the dental appliance. The stable aqueous composition does not require dissolving in a reservoir and may be applied directly to the dental appliance. The aqueous composition is safe for natural teeth and therefore easy to incorporate into a regular oral hygiene routine.