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US Patent 9011853 B7-H4 fusion proteins and methods of use thereof

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Is a
Patent
Patent

Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
9011853
Patent Inventor Names
Solomon Langermann0
Stephen D. Miller0
Joseph R. Podojil0
Linda Liu0
Shannon Marshall0
Date of Patent
April 21, 2015
Patent Application Number
13392811
Date Filed
August 31, 2010
Patent Citations Received
‌
US Patent 11939383 B7-H4 antibodies and methods and use thereof
0
Patent Primary Examiner
‌
Ilia Ouspenski
Patent abstract

Fusion proteins containing B7-H4 polypeptides are disclosed. The B7-H4 fusion proteins can include full-length B7-H4 polypeptides, or can contain a fragment of a full-length B7-H4 polypeptide, including some or all of the extracellular domain of the B7-H4 polypeptide. Methods for using the fusion proteins to downregulate T cell activation and for the treatment of inflammatory and autoimmune diseases and disorders are also disclosed. The B7-H4 fusion proteins are useful for treating inflammation by inhibiting or reducing differentiation, proliferation, activity, and/or cytokine production and/or secretion by ThI, ThI 7, Th22, and/or other cells that secrete, or cause other cells to secrete, inflammatory molecules, including, but not limited to, IL-1β, TNF-α, TGF-beta, IFN-γ, IL-17, IL-6, IL-23, IL-22, IL-21, and MMPs; or enhancing IL-IO secretion by Tregs, increasing the differentiation of Tregs, increasing the number of Tregs, or combinations thereof.

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