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US Patent 8962582 PKR activation via hybridization chain reaction

Patent 8962582 was granted and assigned to California Institute of Technology on February, 2015 by the United States Patent and Trademark Office.

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Patent
Patent

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Current Assignee
California Institute of Technology
California Institute of Technology
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
8962582
Patent Inventor Names
Niles A. Pierce3
Robert Dirks3
Date of Patent
February 24, 2015
Patent Application Number
13154989
Date Filed
June 7, 2011
Patent Citations Received
‌
US Patent 11873485 Allosteric conditional guide RNAs for cell-selective regulation of CRISPR/Cas
1
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2
Patent Primary Examiner
‌
Richard Schnizer
Patent abstract

The present application relates to the use of hybridization chain reaction (HCR) to form double stranded RNA polymers in the presence of a target, such as a nucleic acid associated with a disease or disorder. The RNA polymers are preferably able to activate the RNA-dependent kinase PKR. Activation of PKR via RNA-HCR can be used to treat a wide variety of diseases and disorders by specifically targeting diseased cells.

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