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US Patent 8633163 Template-fixed peptidomimetics

Patent 8633163 was granted and assigned to Polyphor on January, 2014 by the United States Patent and Trademark Office.

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Patent
Patent

Patent attributes

Current Assignee
Polyphor
Polyphor
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
8633163
Patent Inventor Names
Steve J. Demarco1
Heiko Henze1
Odile Sellier-Kessler1
Reshmi Mukherjee1
Alexander Lederer1
Barbara Romagnoli1
Christian Bisang1
Christian Ludin1
...
Date of Patent
January 21, 2014
Patent Application Number
12524862
Date Filed
January 29, 2007
Patent Primary Examiner
‌
Cecilia J. Tsang
Patent abstract

Template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 4 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to agonize or to antagonize GPCR receptors such as CXCR3, urotensin and CCR10. They can be used as medicaments to treat or prevent diseases such as cardiovascular disorders, dermatological disorders, endocrine system and hormone disorders, metabolic diseases, inflammatory diseases, neurological diseases, respiratory diseases, haematological diseases and cancer. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

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