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US Patent 8409861 Targeted deletion of cellular DNA sequences

Patent 8409861 was granted and assigned to Sangamo Biosciences Inc. on April, 2013 by the United States Patent and Trademark Office.

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Patent
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Current Assignee
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
84098611
Patent Inventor Names
Dmitry Guschin1
Michael C. Holmes1
Date of Patent
April 2, 2013
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Patent Application Number
113049811
Date Filed
December 15, 2005
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Patent Citations Received
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US Patent 12129223 Lipids for use in lipid nanoparticle formulations
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US Patent 11690921 Delivery of target specific nucleases
3
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US Patent 11834686 Engineered target specific base editors
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US Patent 11857641 Method for the treatment of mucopolysaccharidosis type I
5
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US Patent 11920169 Compositions for linking DNA-binding domains and cleavage domains
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US Patent 11976019 Cationic lipids for use in lipid nanoparticles
7
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US Patent 11655275 Methods and compositions for modification of a cystic fibrosis transmembrane conductance regulator (CFTR) gene
8
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US Patent 11661611 Genetic modification of cytokine inducible SH2-containing protein (CISH) gene
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Patent Primary Examiner
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Jennifer Dunston
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Patent abstract

Disclosed herein are methods and compositions for targeted deletion of double-stranded DNA. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain, and polynucleotides encoding same. Methods for targeted deletion include introduction of such fusion proteins, or polynucleotides encoding same, into a cell such that two targeted cleavage events occur. Subsequent cellular repair mechanisms result in deletion of sequences between the two cleavage sites.

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