A method of manufacturing a vertical power MOS transistor on a wide band gap semiconductor substrate having a wide band gap superficial semiconductor layer, including the steps of forming a screening structure on the superficial semiconductor layer that leaves a plurality of areas of the superficial semiconductor layer exposed, carrying out at least a first ion implantation of a first type of dopant in the superficial semiconductor layer for forming at least one deep implanted region, carrying out at least a second ion implantation of the first type of dopant in the superficial semiconductor layer for forming at least one implanted body region of the MOS transistor aligned with the deep implanted region, carrying out at least one ion implantation of a second type of dopant in the superficial semiconductor layer for forming at least an implanted source region of the MOS transistor inside the at least one implanted body region, and a low budget activation thermal process of the first and second dopant types suitable to complete the formation of the body region, of the source region, and of the deep implanted region with diffusing the dopants in the substrate.