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US Patent 7790676 Soluble IL-17RA/RC fusion proteins

Patent 7790676 was granted and assigned to ZymoGenetics on September, 2010 by the United States Patent and Trademark Office.

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Current Assignee
ZymoGenetics
ZymoGenetics
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
7790676
Date of Patent
September 7, 2010
Patent Application Number
12055597
Date Filed
March 26, 2008
Patent Primary Examiner
‌
Dong Jiang
Patent abstract

Disclosed are antagonists of IL-17A and IL-17F. The antagonists are based on soluble IL-17RA and IL-17RC fusion proteins, including hybrid soluble receptors comprising portions of both IL-17RC and IL-17RA (“IL-17RC/IL-17RA”). Such antagonists serve to block, inhibit, reduce, antagonize or neutralize the activity of IL-17F, IL-17A, or both IL-17A and IL-17F. Also disclosed are methods of using such antagonists for treating disease, particularly inflammatory diseases mediated at least in part by IL-17A and/or IL-17F.

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