Patent 7662936 was granted and assigned to Genentech on February, 2010 by the United States Patent and Trademark Office.
Methods to detect, screen, and quantitate biological samples after administration of antibody conjugates, antibody-drug conjugates of Formula I, antibodies, and fragments and metabolites thereof, by affinity separation, chromatography, and mass spectrometry are disclosed.Ab-(L-D)p IwhereinAb is an antibody;D is a drug moiety;L is a linker covalently attached to Ab, and covalently attached to D; andp is 1, 2, 3, 4, 5, 6, 7, or 8.