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US Patent 7514444 Inhibitors of bruton's tyrosine kinase

Patent 7514444 was granted and assigned to Pharmacyclics on April, 2009 by the United States Patent and Trademark Office.

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Is a

Patent attributes

Current Assignee

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

Patent Inventor Names

Lee Honigberg0

Zhengying Pan0

Erik Verner0

Date of Patent

April 7, 2009

Patent Application Number

11617645

Date Filed

December 28, 2006

Patent Citations Received

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US Patent 11701357 Treatment of B cell cancers using a combination comprising Btk inhibitors

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Patent Primary Examiner

James O. Wilson

Patent abstract

Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

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