Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ren-He Xu1
James A. Thomson1
Date of Patent
April 7, 2009
1Patent Application Number
111345641
Date Filed
May 20, 2005
1Patent Primary Examiner
Patent abstract
Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem cells in an undifferentiated state. It has now been found that if an antagonist of bone morphogenic protein is added to the medium in which the stem cells are cultured, together with fibroblast growth factor, the stem cells will remain undifferentiated indefinitely, even without feeder cells or conditioned medium.
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