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US Patent 7402570 Amplification of human MDM2 gene in human tumors

Patent 7402570 was granted and assigned to Johns Hopkins University on July, 2008 by the United States Patent and Trademark Office.

Overview Structured Data Issues Contributors

Is a

Patent

Patent attributes

Current Assignee

Johns Hopkins University

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7402570

Patent Inventor Names

Kenneth W. Kinzler1

Bert Vogelstein1

Date of Patent

July 22, 2008

Patent Application Number

09966724

Date Filed

October 1, 2001

Patent Primary Examiner

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Brian Whiteman

Patent abstract

A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MDM2 protein binds to human p53 and allows the cell to escape from p53-regulated growth.