Golden logo
    Create a WorkspaceQuery ToolSaved QueriesDatasetsData RequestsListsPipelinesFollowed Topics
    Invite MembersWorkspace SettingsUpgrade WorkspaceAPI AccessPricingHelp & SupportMore
Log in
Enquire now
‌

US Patent 11959075 Systems and methods for determining nucleic acids

Patent 11959075 was granted and assigned to President and Fellows of Harvard College on April, 2024 by the United States Patent and Trademark Office.

OverviewStructured DataIssuesContributorsActivity

All edits

Edits on 2 Oct, 2024
"update inverses"
Golden AI profile picture
Golden AI
edited on 2 Oct, 2024
Edits made to:
Infobox (+1 properties)
Infobox
Patent Citations Received
‌
US Patent 12104151 Systems and methods for determining nucleic acids
1
1
Type: Web page
Patent. https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/12104151
Edits on 17 Apr, 2024
"Created via: Patent importer"
Golden AI profile picture
Golden AI
created this topic on 17 Apr, 2024
Edits made to:
Infobox (+65 properties)
Article (+969 characters)
‌

 US Patent 11959075 Systems and methods for determining nucleic acids

Article

Patent abstract

The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches.

Infobox
Is a
Patent
Patent
1
Patent Applicant
‌
President and Fellows of Harvard College
1
Current Assignee
‌
President and Fellows of Harvard College
1
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
1
Patent Number
119590751
Patent Inventor Names
Alistair Boettiger1
Jeffrey R. Moffitt1
Kok-Hao Chen1
Siyuan Wang1
Xiaowei Zhuang1
Date of Patent
April 16, 2024
1
Patent Application Number
181849671
Date Filed
March 16, 2023
1
Patent Citations
‌
US Patent 11098303 Systems and methods for determining nucleic acids
1
‌
US Patent 11078520 Method for generating a three-dimensional nucleic acid containing matrix
1
‌
US Patent 7122319 Multiplexed immunohistochemical assays using molecular tags
1
‌
US Patent 7226734 Multiplex decoding of array sensors with microspheres
1
‌
US Patent 7368265 Selective genome amplification
1
‌
US Patent 7455971 Multiplex decoding of array sensors with microspheres
1
‌
US Patent 7473767 Methods for detection and quantification of analytes in complex mixtures
1
‌
US Patent 7499806 Image processing in microsphere arrays
1
‌
US Patent 7629125 Sequential analysis of biological samples
1
‌
US Patent 7727721 Hybridization chain reaction amplification for in situ imaging
1
‌
US Patent 7776613 Sub-diffraction image resolution and other imaging techniques
1
‌
US Patent 7785790 Replica amplification of nucleic acid arrays
1
‌
US Patent 7807447 Compositions and methods for exon profiling
1
‌
US Patent 7838302 Sub-diffraction limit image resolution and other imaging techniques
1
‌
US Patent 7906285 Random array DNA analysis by hybridization
1
‌
US Patent 7910304 Random array DNA analysis by hybridization
1
‌
US Patent 7981604 Methods and kits for analyzing polynucleotide sequences
1
‌
US Patent 8460865 Multiplex decoding of array sensors with microspheres
1
‌
US Patent 8564792 Sub-diffraction limit image resolution in three dimensions
1
‌
US Patent 8741566 Immunohistochemistry and in situ hybridization detection method
1
‌
US Patent 8765642 Combinatorial probe libraries
1
‌
US Patent 9163283 Combinatorial decoding of random nucleic acid arrays
1
‌
US Patent 9201063 Sequential analysis of biological samples
1
‌
US Patent 9359636 Methods for fixing and detecting RNA
1
‌
US Patent 9371598 Spatially encoded biological assays
1
‌
US Patent 9518982 Sequential analysis of biological samples
1
‌
US Patent 9556473 Methods for identifying nucleic acid sequences
1
‌
US Patent 9677125 Detection of plurality of targets in biological samples
1
‌
US Patent 9712805 Sub-diffraction limit image resolution in three dimensions
1
‌
US Patent 9778154 Methods for phenotyping of intact whole tissues
1
‌
US Patent 9850536 Multiplex nucleic acid reactions
1
‌
US Patent 9896720 Imaging individual mRNA molecules using multiple singly labeled probes
1
‌
US Patent 9944972 High-throughput and highly multiplexed imaging with programmable nucleic acid probes
1
‌
US Patent 10073035 Sub-diffraction limit image resolution and other imaging techniques
1
‌
US Patent 10190151 High-throughput and highly multiplexed imaging with programmable nucleic acid probes
1
‌
US Patent 10227639 Compositions and methods for analyte detection
1
‌
US Patent 10240146 Probe library construction
1
‌
US Patent 10266876 Multiplex detection of molecular species in cells by super-resolution imaging and combinatorial labeling
1
‌
US Patent 10267808 Molecular indicia of cellular constituents and resolving the same by super-resolution technologies in single cells
1
‌
US Patent 10457980 Multiplex labeling of molecules by sequential hybridization barcoding
1
‌
US Patent 10501791 Sequencing by structure assembly
1
‌
US Patent 10510435 Error correction of multiplex imaging analysis by sequential hybridization
1
‌
US Patent 10526649 Augmenting in situ nucleic acid sequencing of expanded biological samples with in vitro sequence information
1
‌
US Patent 10545075 Methods and compositions for preparing biological specimens for microscopic analysis
1
‌
US Patent 10563257 In situ nucleic acid sequencing of expanded biological samples
1
‌
US Patent 10829814 Methods and compositions for single cell genomics
1
‌
US Patent 10870846 Cellular high throughput encapsulation for screening or selection
1
‌
US Patent 10961566 Spatially encoded biological assays
1
‌
US Patent 11021737 Compositions and methods for analyte detection
1
‌
US Patent 11788123 Systems and methods for high-throughput image-based screening
1
‌
US Patent 7033754 Decoding of array sensors with microspheres
1
Patent Primary Examiner
‌
Joseph Woitach
1
1
Type: Web page
Patent. https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/11959075

Find more entities like US Patent 11959075 Systems and methods for determining nucleic acids

Use the Golden Query Tool to find similar entities by any field in the Knowledge Graph, including industry, location, and more.
Open Query Tool
Access by API
Golden Query Tool
Golden logo

Company

  • Home
  • Press & Media
  • Blog
  • Careers
  • WE'RE HIRING

Products

  • Knowledge Graph
  • Query Tool
  • Data Requests
  • Knowledge Storage
  • API
  • Pricing
  • Enterprise
  • ChatGPT Plugin

Legal

  • Terms of Service
  • Enterprise Terms of Service
  • Privacy Policy

Help

  • Help center
  • API Documentation
  • Contact Us
By using this site, you agree to our Terms of Service.
  • Create Issue
  • View Changes
  • Create Issue
  • View Changes
    • Home
    • Product
    • Data CreditsNEW
    • DatasetsNEW
    • ChatGPT Plugin
    • API
    • CRM Integration
    • Careers
    • Blog

    • Terms of Service
    • API Documentation

  • Contact Us
  • Content Issue