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US Patent 11891605 Reducing intron retention

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Patent abstractTimelineTable: Further ResourcesReferences
Is a
Patent
Patent
1

Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
1
Patent Number
118916051
Patent Inventor Names
Igor Vorechovsky1
Jana Kralovicova1
Date of Patent
February 6, 2024
1
Patent Application Number
178467941
Date Filed
June 22, 2022
1
Patent Citations
‌
US Patent 9192621 Esters and malonates of SATE prodrugs
1
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US Patent 9745577 Reducing intron retention
1
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US Patent 9771579 Treatment of sodium channel, voltage-gated, alpha subunit (SCNA) related diseases by inhibition of natural antisense transcript to SCNA
1
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US Patent 9976143 Targeted augmentation of nuclear gene output
1
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US Patent 10196639 Modulation of gene expression and screening for deregulated protein expression
1
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US Patent 10538764 Reducing intron retention
1
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US Patent 10696969 Targeted augmentation of nuclear gene output
1
‌
US Patent 11390869 Reducing intron retention
1
...
Patent Primary Examiner
‌
Amy H Bowman
1
CPC Code
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C12N 2310/11
1
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C12N 15/113
1
Patent abstract

Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.

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