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US Patent 11788123 Systems and methods for high-throughput image-based screening

Patent 11788123 was granted and assigned to President and Fellows of Harvard College on October, 2023 by the United States Patent and Trademark Office.

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Contents

Patent abstractTimelineTable: Further ResourcesReferences
Is a
Patent
Patent

Patent attributes

Patent Applicant
‌
President and Fellows of Harvard College
Current Assignee
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President and Fellows of Harvard College
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
11788123
Patent Inventor Names
Xiaowei Zhuang
Jeffrey R. Moffitt
George Alexander Emanuel
Date of Patent
October 17, 2023
Patent Application Number
16616833
Date Filed
May 25, 2018
Patent Citations
‌
US Patent 7499806 Image processing in microsphere arrays
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US Patent 7629125 Sequential analysis of biological samples
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US Patent 7727721 Hybridization chain reaction amplification for in situ imaging
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US Patent 7776613 Sub-diffraction image resolution and other imaging techniques
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US Patent 7785790 Replica amplification of nucleic acid arrays
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US Patent 7122319 Multiplexed immunohistochemical assays using molecular tags
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US Patent 7226734 Multiplex decoding of array sensors with microspheres
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US Patent 7368265 Selective genome amplification
...
Patent Citations Received
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US Patent 11959075 Systems and methods for determining nucleic acids
1
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US Patent 12104151 Systems and methods for determining nucleic acids
2
Patent Primary Examiner
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David C Thomas
CPC Code
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C40B 70/00
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C40B 30/04
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C12Q 1/6841
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C12Q 2525/161
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C12Q 2563/179
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C12Q 2565/514
Patent abstract

The present invention generally relates to imaging cells, for example, to determine phenotypes and/or genotypes in populations of cells. The cells may be exposed to a nucleic acid comprising an identification portion, which may be used to distinguish the cells from each other. In some embodiments, the cells may be exposed to a nucleic acid comprising an expression portion. The identification portion, the expression portion, or both may be introduced into the genome of a host organism or as exogenous materials, e.g. plasmids.

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