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US Patent 11752181 Compositions and methods of treating Huntington's disease

Patent 11752181 was granted and assigned to Voyager Therapeutics on September, 2023 by the United States Patent and Trademark Office.

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US Patent 12084659 Modulatory polynucleotides
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 US Patent 11752181 Compositions and methods of treating Huntington's disease

Article

The present invention relates to adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating Huntington's Disease (HD).

Infobox
Is a
Patent
Patent
Patent Applicant
Voyager Therapeutics
Voyager Therapeutics
Current Assignee
Voyager Therapeutics
Voyager Therapeutics
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
11752181
Patent Inventor Names
Dinah Wen-Yee Sah
Fen Chen
Jinzhao Hou
Jochen Deckert
Markus Hossbach
Pengcheng Zhou
Xin Wang
Yanqun Shu
Date of Patent
September 12, 2023
Patent Application Number
16611041
Date Filed
May 4, 2018
Patent Citations
‌
US Patent 7091030 Composition for the preservation of viruses
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US Patent 7094604 Production of pseudotyped recombinant AAV virions
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US Patent 7105345 Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
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US Patent 7112321 Adeno-associated virus-mediated delivery of GDNF to skeletal muscles
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US Patent 7125705 Polynucleotides for use in recombinant adeno-associated virus virion production
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US Patent 7125706 Method for the production and purification of adenoviral vectors
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US Patent 7169612 Use of EDG2 receptor in an animal model of heart failure
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US Patent 7186552 Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
‌
US Patent 7198951 Adeno-associated virus (AAV) serotype 9 sequences, vectors containing same, and uses therefor
‌
US Patent 7223585 Viral purification methods
‌
US Patent 7235393 Method for direct rescue and amplification of integrated viruses from cellular DNA of tissues
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US Patent 7238526 Methods and cell line useful for production of recombinant adeno-associated viruses
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US Patent 7241447 Adeno-associated virus vectors and uses thereof
‌
US Patent 7247472 Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
‌
US Patent 7271002 Production of adeno-associated virus in insect cells
‌
US Patent 7282199 Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor
‌
US Patent 7291498 Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
‌
US Patent 7300797 Lysis reagent for blood cell analysis
‌
US Patent 7306794 Methods and compositions for the treatment of defects in lipoprotein metabolism
‌
US Patent 7319002 Method for purification of viral vectors having proteins which bind sialic acid
‌
US Patent 7326555 Methods of adenovirus purification
‌
US Patent 7344872 Method for rapid screening of bacterial transformants and novel simian adenovirus proteins
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US Patent 7419817 Scalable purification of AAV2, AAV4 or AAV5 using ion-exchange chromatography
‌
US Patent 7419956 Isolated physiologically active peptide and use thereof
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US Patent 7445930 Method for the production and purification of adenoviral vectors
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US Patent 7479554 AAV5 nucleic acids
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US Patent 7491508 Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
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US Patent 7510872 Recombinant adeno-associated virus production
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US Patent 7510875 Methods for producing purified adenoviral vectors
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US Patent 7579181 Purification of adenovirus and AAV
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US Patent 7625570 Methods for purifying adeno-associated virus
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US Patent 7638120 High transgene expression of a pseudotyped adeno-associated virus type
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US Patent 7662627 Adeno-associated virus materials and methods
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US Patent 7704492 Methods for delivering DNA to muscle cells using recombinant adeno-associated virus virions
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US Patent 7704721 Compositions and methods to prevent AAV vector aggregation
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US Patent 7732129 Method for the production and purification of adenoviral vectors
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US Patent 7790449 Adeno-associated virus (AAV) serotype 8 sequences, vectors containing the same, and uses therefor
‌
US Patent 7803622 Adeno-associated virus vectors
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US Patent 7838277 Method for rapid screening of bacterial transformants and novel simian adenovirus proteins
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US Patent 7888096 Liquid adenovirus formulations
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US Patent 7901921 Viral purification methods
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US Patent 7906111 Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses therefor
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US Patent 7968333 Adenovirus vectors containing cell status-specific response elements and methods of use thereof
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US Patent 8105574 Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
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US Patent 8110351 Method for isolating nucleic acids and protein from a single sample
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US Patent 8137948 Methods for producing preparations of recombinant AAV virions substantially free of empty capsids
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US Patent 8163543 AAV vectors produced in insect cells
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US Patent 8231880 Simian subfamily C adenoviruses SAdV-40, -31, and -34 and uses thereof
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US Patent 8236495 Process and equipment for plasmid purification
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US Patent 8241622 Adeno-associated virus vectors with intravector heterologous terminal palindromic sequences
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US Patent 8273344 Recombinant adeno-associated virus expressing human antisense gene CyP2J2 and its preparation methods
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US Patent 8283151 Isolation, cloning and characterization of new adeno-associated virus (AAV) serotypes
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US Patent 8318480 Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor
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US Patent 8318687 Recombinant adeno-associated virus vector for treatment of Alzheimer disease
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US Patent 8394386 Sequential delivery of immunogenic molecules via adenovirus and adeno-associated virus-mediated administrations
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US Patent 8409842 Recombinant adeno-associated virus production
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US Patent 8470310 Simian adenoviruses SAdV-36, -42.1, -42.2, and -44 and uses thereof
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US Patent 8476418 Modified AAV capsid polypeptides
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US Patent 8512981 Vectors with modified initiation codon for the translation of AAV-Rep78 useful for production of AAV
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US Patent 8524219 Simian subfamily B adenoviruses SAdV-28, -27, -29, -32, -33, and -35 and uses thereof
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US Patent 8524446 Method for detecting adeno-associated virus
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US Patent 11193129 Modulatory polynucleotides
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US Patent 11198873 Modulatory polynucleotides
‌
US Patent 8603459 Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
‌
US Patent 8614101 In situ lysis of cells in lateral flow immunoassays
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US Patent 8637255 Adeno-associated virus serotype I nucleic acid sequences, vectors and host cells containing same
‌
US Patent 8642314 Optimization of expression of parvoviral rep and cap proteins in insect cells
‌
US Patent 8685734 Viral purification methods
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US Patent 8697417 Baculoviral vectors comprising repeated coding sequences with differential codon biases
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US Patent 8697665 Porphobilinogen deaminase gene therapy
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US Patent 8834863 Subfamily E simian adenoviruses A1321, A1325, A1295, A1309, A1316 and A1322 and uses thereof
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US Patent 8846030 Compounds and methods to enhance rAAV transduction
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US Patent 8846389 AAV4 vector and uses thereof
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US Patent 8906387 In vivo transduction with a chimeric AAV capsid protein
‌
US Patent 8906675 Adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby
‌
US Patent 8927514 Recombinant adeno-associated vectors for targeted treatment
‌
US Patent 8962330 Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor
‌
US Patent 8962332 Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor
‌
US Patent 8999678 Method of increasing the function of an AAV vector
‌
US Patent 9051542 Compositions and methods to prevent AAV vector aggregation
‌
US Patent 9056892 Retrograde transport peptide and use of same for delivery to central nervous system
‌
US Patent 9080183 Promoter
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US Patent 9089667 Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery
‌
US Patent 9101645 Modulation of axon degeneration
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US Patent 9102943 Method for producing virus vector
‌
US Patent 9115373 Use of AAV replication machinery for improved protein production
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US Patent 9163260 Adeno-associated virus serotype I nucleic acid sequences, vectors and host cells containing same
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US Patent 9169483 RNA interference suppression of neurodegenerative diseases and methods of use thereof
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US Patent 9217155 Isolation of novel AAV'S and uses thereof
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US Patent 9217159 Subfamily E simian adenoviruses A1302, A1320, A1331 and A1337 and uses thereof
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US Patent 9228174 Mutated rep encoding sequences for use in AAV production
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US Patent 9233174 Minicircle DNA vector preparations and methods of making and using the same
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US Patent 9238800 Avian adenoassociated virus and uses thereof
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US Patent 9260724 Optimization of expression of parvoviral rep and cap proteins in insect cells
‌
US Patent 9415121 Delivery of MECP2 polynucleotide using recombinant AAV9
‌
US Patent 9434776 Methods and compositions for gene inactivation
‌
US Patent 9439979 Epidermal growth factor receptor (EGFR) and methods of use in adenoviral-associated virus type 6 (AAV6) transduction
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US Patent 9441206 Cell line for production of adeno-associated virus
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US Patent 9441244 Mutant adeno-associated virus virions and methods of use thereof
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US Patent 9447433 Synthetic adeno-associated virus inverted terminal repeats
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US Patent 9457103 Adeno-associated virus virions with variant capsid and methods of use thereof
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US Patent 9458517 Adeno-associated virus virions with variant capsid and methods of use thereof
‌
US Patent 9464119 Assembly activating protein (AAP) and its use for the manufacture of parvovirus particles essentially consisting of VP3
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US Patent 9475845 Modified virus vectors and methods of making and using the same
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US Patent 9487779 siRNA-mediated gene silencing
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US Patent 9493788 Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor
‌
US Patent 9499597 Methods and compositions for treating Huntington's disease
‌
US Patent 9506083 AAV virions with decreased immunoreactivity and uses therefor
‌
US Patent 9523093 Huntington's disease therapeutic compounds
‌
US Patent 9528126 Methods for producing preparations of recombinant AAV virions substantially free of empty capsids
‌
US Patent 9540659 Modified adeno-associated virus vector compositions
‌
US Patent 9546112 Methods of increasing efficiency of vector penetration of target tissue
‌
US Patent 9546369 Multicistronic expression constructs
‌
US Patent 9567376 Enhanced AAV-mediated gene transfer for retinal therapies
‌
US Patent 9567607 Adeno-associated virus serotype I nucleic acid sequences, vectors and host cells containing same
‌
US Patent 9580691 Baculoviral vectors comprising repeated coding sequences with differential codon biases
‌
US Patent 9585971 Recombinant AAV capsid protein
‌
US Patent 9587250 Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor
‌
US Patent 9587282 Adeno-associated virus virions with variant capsid and methods of use thereof
‌
US Patent 9593346 Simian adenoviruses SAdV-43, -45, -46, -47, -48, -49, and -50, and uses thereof
‌
US Patent 9596835 Isolation of novel AAV's and uses thereof
‌
US Patent 9597363 Simian adenoviruses SAdV-36, -42.1, -42.2, and -44 and uses thereof
‌
US Patent 9598468 Polypeptides and vectors for targeting HER2/
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US Patent 9598703 Capsid-free AAV vectors, compositions, and methods for vector production and gene delivery
‌
US Patent 9611302 High-transduction-efficiency RAAV vectors, compositions, and methods of use
‌
US Patent 9617561 Simian adenovirus 41 and uses thereof
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US Patent 9623120 Recombinant adeno-associated vectors for targeted treatment
‌
US Patent 9624274 Mutated structural protein of a parvovirus
‌
US Patent 9636370 AAV vectors targeted to oligodendrocytes
‌
US Patent 9650631 Reduction of off-target RNA interference toxicity
‌
US Patent 9670507 Directed evolution and in vivo panning of virus vectors
‌
US Patent 9677088 Adeno associated virus plasmids and vectors
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US Patent 9677089 Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor
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US Patent 9719106 Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
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US Patent 10093927 Reduction of off-target RNA interference toxicity
‌
US Patent 10174321 RNAI induced huntingtin gene suppression
‌
US Patent 10208318 CNS gene delivery using peripheral administration of AAV vectors
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US Patent 10570395 Modulatory polynucleotides
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US Patent 10584337 Modulatory polynucleotides
Patent Primary Examiner
‌
James D Schultz
CPC Code
‌
C12N 15/113
‌
A61K 35/76

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