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US Patent 11698377 Methods for detecting AAV

Patent 11698377 was granted and assigned to Genzyme on July, 2023 by the United States Patent and Trademark Office.

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Is a
Patent
Patent
1

Patent attributes

Patent Applicant
Genzyme
Genzyme
1
Current Assignee
Genzyme
Genzyme
1
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
1
Patent Number
116983771
Date of Patent
July 11, 2023
1
Patent Application Number
163256531
Date Filed
August 14, 2017
1
Patent Citations
‌
US Patent 8283151 Isolation, cloning and characterization of new adeno-associated virus (AAV) serotypes
1
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US Patent 7588772 AAV capsid library and AAV capsid proteins
1
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US Patent 7629322 AAV vector for gene therapy
1
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US Patent 9169299 AAV capsid proteins for nucleic acid transfer
1
Patent Citations Received
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US Patent 12123880 Methods for detecting AAV
2
Patent Primary Examiner
‌
Xiaoyun R Xu
1

Provided herein are methods for determining the serotype of a virus particle and/or or determining the heterogeneity of a virus particle (e.g., an AAV particle). In other embodiments, the invention provides methods to determine the heterogeneity of AAV particles. In some aspects, the invention provides viral particles (e.g., rAAV particles) with improved stability and/or improved transduction efficiency by increasing the acetylation and/or deamidation of capsid proteins.

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