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US Patent 11692224 Synthetic nucleic acid spike-ins

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Is a
Patent
Patent
1

Patent attributes

Patent Applicant
Karius
Karius
1
Current Assignee
Karius
Karius
1
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
1
Patent Number
116922241
Date of Patent
July 4, 2023
1
Patent Application Number
173558821
Date Filed
June 23, 2021
1
Patent Citations
‌
US Patent 8703652 Non-invasive diagnosis of graft rejection in organ transplant patients
1
‌
US Patent 9194006 Direct amplification and detection of viral and bacterial pathogens
1
‌
US Patent 9353414 Noninvasive diagnosis of fetal aneuploidy by sequencing
1
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US Patent 9892230 Size-based analysis of fetal or tumor DNA fraction in plasma
1
‌
US Patent 9976181 Synthetic nucleic acid spike-ins
1
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US Patent 10240200 Methods for profiling and quantitating cell-free RNA
1
‌
US Patent 10450620 Cell-free nucleic acids for the analysis of the human microbiome and components thereof
1
‌
US Patent 10697008 Sample preparation methods, systems and compositions
1
...
Patent Primary Examiner
‌
Aaron A Priest
1
CPC Code
‌
C12Q 1/68
1

This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.

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