A machine learning multi-dimensional acoustic feature vector authentication system, according to an example of the present disclosure, builds and trains multiple multi-dimensional acoustic feature vector machine learning classifiers to determine a probability of spoofing of a voice. The system may extract an acoustic feature from a voice sample of a user. The system may convert the acoustic feature into multi-dimensional acoustic feature vectors and apply the multi-dimensional acoustic feature vectors to the multi-dimensional acoustic feature vector machine learning classifiers to detect spoofing and determine whether to authenticate a user.