A tissue dispenser includes a hollow housing having a front surface, a rear surface, and two opposing hinged side doors that provide selective access to an interior tissue chamber. Each side door includes a dispensing slot through which a tissue is dispensed from the tissue chamber. On the rear surface are a pair of spring-biased, V-shaped clamps for releasably gripping a side edge of a passenger seat. Accordingly, when the housing is secured to the vehicle passenger seat, a tissue can be removed from either slot, thereby providing easy access by a passenger sealed within either the front or rear seats.