Patent 10336818 was granted and assigned to Xencor on July, 2019 by the United States Patent and Trademark Office.
The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.