A cryptographic ASIC and method for autonomously storing data into a one-time programmable memory in isolation. Internal circuitry provides programming pulses of a given voltage magnitude and duration for changing the state of selected memory elements. Use of internal circuitry reduces pin count and increases reliability and security over devices relying on external circuitry to provide programming pulses. In one embodiment, the stored data comprises cryptographic data for enforcing a derivative key hierarchy for managing an information stream, such as a blockchain.