Intersouth Partners is a venture capital firm that is headquartered in Durham, North Carolina. The firm was founded in 1985 by Dennis Dougherty and Roy Rodwell. Based in North Carolina's Research Triangle, Intersouth Partners invests in locally based technology and life sciences companies. The firm aims to boost the development of its target industries in North Carolina's piedmont. The firm's first fund was raised in 1985 and was valued at $6.4 million dollars. The second fund was raised in 1989. It was announced in 2017 that the firm would no longer be investing in new companies.