Circle Pharma

Circle Pharma operates an indication-agnostic discovery engine for the development of cell permeable macrocyclic peptide therapeutics. Computational structure-based design is combined with automated, fully synthetic chemistry. In the computational design workflow, large virtual libraries of diverse macrocycles for intrinsic cell permeability and target affinity are generated and screened. Circle Pharma’s technology allows them to target intracellular targets such as protein-protein interactions and achieve oral bioavailability. The automated chemistry synthesis is used to assess in parallel multiple design hypotheses for a given target and rapidly explore structure activity relationships. Circle Pharma is initially focused on intracellular protein-protein interactions that drive oncology pathways.