St. Louis Arch Angels is a venture capital and private equity firm investing in startup companies in the St.Louis ecosystem that is headquartered in St.Louis, Missouri and was founded in 2005. The firm invests in startups originating within universities, research institutions, companies, and technology incubators in the St.Louis area. Corporate Sponsors of St. Louis Arch Angels are Anders, Commerce Bank, and Polsinelli.
St. Louis Arch Angels has made 92 investments, has 43 companies in its portfolio, and 18 exits. Notable investments made by the firm include: Lean Media, Aptimmune, Covercress, Euclises Pharmaceuticals, Greetabl, FocalCast, and Confluence Life Sciences.