Restylane is the trade name for a range of injectable fillers with a specific formulation of non-animal sourced hyaluronic acid (HA).In the United States, Restylane was the first hyaluronic acid filler to be approved by the U.S. Food and Drug Administration (FDA) for cosmetic injection into subdermal facial tissues
Restylane is most commonly used for lip enhancement (volume and contouring). It is used to diminish wrinkles and aging lines of the face such as the nasolabial folds (nose to mouth lines) and melomental folds (sad mouth corners). It may also be used for filling aging-related facial hollows and "orbital troughs" (under and around the eyes), as well as for cheek volume and contouring of the chin, lips and nose.
Side effects
A treatment with a dermal filler like Restylane can cause some temporary bruising in addition to swelling and numbness for a few days. In rare cases there has been reports of lumps or granulomas. These side effects can be easily reversed with a treatment of hyaluronidase, which is an enzyme that speeds up the natural degradation of the injected hyaluronic acid filler.Several studies have been done to understand the long-term side effects of restylane and other hyaluronic acid fillers.
In certain cases, the filler results in a granulomatous foreign body reaction.Even though side effects are rare Restylane should not be used in or near areas where there is or has been skin disease, inflammation or related conditions. Restylane has not been tested in pregnant or breast-feeding women.
The Restylane family of products are indicated for patients over the age of 21, and includes Restylane®, Restylane-L®, Restylane® Lyft with Lidocaine, Restylane® Silk, Restylane® Kysse, Restylane® Refyne, Restylane® Defyne, and Restylane® Contour.
APPROVED USES
Restylane® and Restylane-L® are for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds.
Restylane® and Restylane-L® are also indicated for injection into the lips.
Restylane® Lyft with Lidocaine is for deep implantation into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds and for cheek augmentation and for the correction of age-related midface contour deficiencies.
Restylane® Lyft with Lidocaine is also indicated for injection into the dorsal hand to correct volume loss.Restylane® Silk is for lip augmentation and for correction of perioral wrinkles.Restylane® Kysse is for lip augmentation and for correction of upper perioral wrinkles.
Restylane® Refyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds.
Restylane® Defyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe deep facial wrinkles and folds, such as nasolabial folds.
Restylane® Defyne is also indicated for injection into the mid-to-deep dermis (subcutaneous and/or supraperiosteal) for augmentation of the chin region to improve the chin profile in patients with mild to moderate chin retrusion.
Restylane® Contour is for cheek augmentation and for the correction of midface contour deficiencies.
Do not use if you have severe allergies with a history of severe reactions (anaphylaxis), are allergic to lidocaine or gram-positive bacterial proteins used to make hyaluronic acid, prone to bleeding, or have a bleeding disorder. The safety of use while pregnant or breastfeeding has not been studied. Tell your doctor if you have a history of scarring or pigmentation disorders as these side effects can occur with hyaluronic acid fillers.
Tell your doctor if you are planning other cosmetic treatments (i.e., lasers and chemical peels) as there is a possible risk of inflammation at the injection site.Tell your doctor if you’re taking medications that lower your body’s immune response or affect bleeding, such as aspirin or warfarin, as these medications may increase the risk of bruising or bleeding at the gel injection site.
Using these products on gel injection sites with skin sores, pimples, rashes, hives, cysts, or infections should be postponed until healing is complete.
The most common side effects are swelling, redness, pain, bruising, headache, tenderness, lump formation, itching at the injection site, and impaired hand function. Serious but rare side effects include delayed onset infections, recurrence of herpetic eruptions, and superficial necrosis at the injection site. The risk of unintentional injection into a blood vessel is small but can occur and could result in serious complications, which may be permanent including, vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin. As with all skin injection procedures, there is a risk of infection.
