Andrzejewski (née Weber) had an interest in technology from a young age, learning to reprogram her childhood computer at eight years old and design websites for local businesses by the time she was in junior high school.
After graduating from college, Andrzejewski joined a design firm called Adaptive Path in San Francisco, California. In 2009, Andrzejewski was inspired to launch Foodspotting, an app that allows users to socially share their food photographs, after being unable to find the Japanese dish okonomiyaki in San Francisco. She began the project alongside programmer Ted Grubb and social media strategist Soraya Darabi. Billed as a "visual guide to food," the app allows users to enter their city and a type of food to get photos showing local restaurants that carry the dish. Since its launch, the service has been named to Time's list of 50 Best Websites of 2010 and featured at Facebook's f8 conference.
Foodspotting was acquired by OpenTable in 2013 for $10 million. As part of the acquisition, Andrzejewski joined the online reservation platform as a lead user interface designer.