Daddario made his major film debut as Aaron in the romantic drama film Breathe In, directed by Drake Doremus.[7] That same year, he had a supporting role as Channing in the Vince Vaughn-led comedy film Delivery Man, directed by Ken Scott. In 2014, Daddario portrayed Danny Ladouceur in the sports drama film When the Game Stands Tall, co-starring alongside Jim Caviezel, Laura Dern, and Alexander Ludwig. The film is based on the achievements of football coach Bob Ladouceur and the De La Salle Spartans, who set a record 151-game winning streak.
He received a variety of nominations including Teen Choice Awards and GLAAD awards for his performance in the same. The series began airing on January 12, 2016,[8] and ended on May 6, 2019.[9] Also in 2016, he starred in the remake of Eli Roth's horror film Cabin Fever, directed by Travis Z.[10] In 2020, he joined the cast of Why Women Kill for the show's second season. He portrayed Scooter, a wannabe actor described as "charming but not so bright."
