Hydroxychloroquine sulfate is sold under the drug names Plaquenil and Ercoquin and used as a treatment or prophylaxis of malaria. Hydroxychloroquine is also used to treat lupus erythematosus and rheumatoid arthritis. Chloroquine is also given as a drug in the form of chloroquine phosphate under the drug name Aralen for the same indications. Overdose of chloroquine phosphate can cause acute poisoning and death. Hydroxychloroquine sulfate is a derivative of chloroquine phosphate that has been demonstrated to be 40% less toxic than chloroquine phosphate in animals, but prolonged and overdose usage can still cause poisoning.
Hydroxychloroquine sulfate is being tested in clinical trials for COVID-19 and has been shown to inhibit SARS-CoV-2 infection in vitro, in Vero E6 cells in culture.
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- Cluster: COVID-19A cluster of topics related to COVID-19. COVID-19 is the abbreviated name for coronavirus disease 2019, a respiratory disease caused by a novel coronavirus strain called SARS-CoV-2. COVID-19 was first detected in Wuhan City, China and the outbreak was declared a pandemic on March 11, 2020 by the WHO.