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After graduating from the Moscow Higher Technical School in 1928, A.I. Tselikov worked as a designer at Stalproekt and then at the Serp & Molot and Izhora metallurgical plants. Since 1935 he taught in technical institutes; since 1949 he was Professor and Head of the Department at the Moscow Higher Technical School, in 1950s he was Head of the laboratory of metal forming at the Institute for Engineering Science, simultaneously he worked at the Central Design Office for Metallurgical Engineering as a Department Head and then Head of this Office.
In 1953 L.I. Tselikov was elected a corresponding member, and in 1964 - a full member of the Academy of Science of the USSR. He had been an initiator of creation of a new scientific institution in respect of goals and tasks, the All-Union Scientific Research and Design Institute of Metallurgical Machine Building. Since the establishment of the Institute in 1959, A.I. Tselikov was its permanent director for twenty five years. He played a great role in the organization of scientific and design works in the field of creation of new machines and technological processes for various branches of Soviet mechanical engineering.
The main scientific works of academician A.I. Tselikov were devoted to theoretical issues of metal rolling, problems of designing of rolling mills and other metallurgical units. He developed the theory of rolling and original methods of calculation of rolling mills. Under his supervision and participation he created and introduced into industry original mills and units - blooming, continuous pipe-rolling and pipe-welding mills, forging presses with capacity of 75 thousand tons, he developed technology and units for combining continuous casting with rolling and welding of tubes with rolling. Of great importance for mechanical engineering are radically new processes of rolling of periodic sections, balls, screws, axles, cogwheels, and other critical engineering products developed under the leadership of A. I. Tselikov.
Academician A. I. Tselikov is the author of many monographs, which became widely known among specialists and served as a base for preparation of several generations of metallurgical engineering engineers. His first big work "Calculation and design of rolling-machine tools" was published in 1938; afterwards he published many other scientific works, edited numerous collections and reference books. A. I. Tselikov's outstanding contribution to the development of science and industry was marked with the high title of Hero of Socialist Labor (twice), three Stalin Prizes (1947, 1948, 1951), Lenin Prize (1964) and Lomonosov Gold Medal (1964). He was awarded the Lomonosov Gold Medal by the USSR Academy of Sciences in 1974.