Jule Brand first played in the youth teams at F.V. Dudenhofen and at JSG JFV Ganerbe before getting into the youth division of TSG 1899 Hoffenheim in the winter of 2018 through the juniors of FC Speyer 09. There she first played in the U-17, and then in the U20 in the 2nd Bundesliga. After 37 matches on points, she reached the first team in 2020.

In the 2020/21 Federal League season, she took 3rd place with Hoffenheim and was in the UEFA Women's Champions League 2021/22, she qualified with Hoffenheim women and reached the first group stage. But here they had to partially pay for training against last year's winners Barcelona and Arsenal and were eliminated as group strikes. Brando played in nine matches and scored three goals.

