Clinical Studies Sponsored by Spero Therapeutics | 18 results

Study to Assess the Intrapulmonary Pharmacokinetics of SPR859 by Comparing the Plasma, Epithelial Lining Fluid (ELF), and Alveolar Macrophages (AM) Concentrations Following the Oral Administration of Five Doses of SPR994 in Healthy, Nonsmoking Volunteers

Name	NCT Number	Health Conditions in Trial	Clinical Trial Start Date	Study Completion Date	Clinical Trial Study Type
‌ A Study of the Safety, Tolerability, and Pharmacokinetics of SPR720 in Healthy Volunteers	NCT03796910		December 18, 2018	September 24, 2019	Interventional
‌ Study to Examine the Effect of Antacid and Omeprazole on the Single-Dose Pharmacokinetics of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Healthy Adult Subjects	NCT04368585		July 1, 2020	August 21, 2020	Interventional
‌ Phase 1 Study of PK and Safety of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Subjects With Various Degrees Of Renal Function	NCT04178577		December 6, 2019	September 11, 2020	Interventional
‌ A First in Human Study of the Safety and Tolerability of Single and Multiple Doses of SPR206 in Healthy Volunteers	NCT03792308		December 18, 2018	December 23, 2019	Interventional
‌ Safety, Tolerability, Pharmacokinetics and Efficacy of SPR720 for the Treatment of Patients With Mycobacterium Avium Complex (MAC) Pulmonary Disease	NCT04553406	‌ Mycobacterium avium complex	December 3, 2020	January 28, 2021	Interventional
‌ A First in Human Study of the Safety and Tolerability of Single and Multiple Doses of SPR741 in Healthy Volunteers	NCT03022175		2016	2017	Interventional
‌ Phase 1 Study to Evaluate DDI, PK, Safety, Tolerability of SPR741	NCT03376529		November 10, 2017	December 20, 2017	Interventional
‌ A Study to Assess the Intrapulmonary Pharmacokinetics (PK) of SPR719 by Comparing the Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations Following the Oral Administration of Multiple Doses of SPR720 in Healthy Volunteers	NCT05955586		August 1, 2023	January 24, 2024	Interventional
‌ Bioequivalence Study Comparing Two Tablet Formulations of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Healthy Adult Subjects	NCT04421885		June 1, 2020	July 29, 2020	Interventional
‌ Study to Assess the Efficacy, Safety and Pharmacokinetics of Orally Administered Tebipenem Pivoxil Hydrobromide (SPR994) Compared to Intravenous Ertapenem in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)	NCT03788967		June 3, 2019	May 27, 2020	Interventional
‌ Phase 1 Study of Safety, Tolerability and Pharmacokinetics of SPR994	NCT03395249		October 20, 2017	August 2, 2018	Interventional
‌ Study of the Absorption, Metabolism, and Excretion of [14C]-Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) Following a Single Oral Dose in Healthy Male Subjects	NCT04625855		September 30, 2020	October 16, 2020	Interventional
‌ A Single-Dose, Randomized, Placebo- and Active-Control, Four-Way, Cross-Over Study for the Evaluation of the Effect of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) on the QT/QTc Intervals in Adult Healthy Subjects	NCT04238195		January 19, 2020	February 26, 2020	Interventional
‌ Study to Assess the Intrapulmonary Pharmacokinetics of SPR206 in Healthy Volunteers	NCT04868292		June 3, 2021	September 29, 2021	Interventional
‌ Study to Assess the Intrapulmonary Pharmacokinetics of SPR859 by Comparing the Plasma, Epithelial Lining Fluid (ELF), and Alveolar Macrophages (AM) Concentrations Following the Oral Administration of Five Doses of SPR994 in Healthy, Nonsmoking Volunteers	NCT04710407		December 7, 2020	March 10, 2021	Interventional
‌ A Study to Compare Two Bioanalytical Assays for Tebipenem	NCT05856747		May 4, 2023	June 1, 2023	Interventional
‌ Phase 1 Study of PK and Safety of SPR206 in Subjects With Various Degrees Of Renal Function	NCT04865393		June 8, 2021	December 6, 2021	Interventional
‌ Effect of Tebipenem on Normal Human Intestinal Microbiota	NCT04376554		February 10, 2020	April 6, 2021	Interventional