Clinical Studies Sponsored by Nektar Therapeutics | 28 results

A Study of Bempegaldesleukin (NKTR-214: BEMPEG) in Combination With Nivolumab Compared With the Investigator's Choice of a Tyrosine Kinase Inhibitor (TKI) Therapy (Either Sunitinib or Cabozantinib Monotherapy) for Advanced Metastatic Renal Cell Carcinoma (RCC)

Name	NCT Number	Health Conditions in Trial	Clinical Trial Start Date	Study Completion Date	Clinical Trial Study Type
‌ A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Severe to Very Severe Alopecia Areata in Adult Patients (Rezolve AA)	NCT06340360	Alopecia areata	March 27, 2024	2026	Interventional
‌ BEMPEG With Pembrolizumab vs Pembrolizumab Alone in Patients With Metastatic or Recurrent HNSCC (PROPEL-36)	NCT04969861		March 9, 2022	April 22, 2022	Interventional
‌ A CD8 Positron Emission Tomography With Computed Tomography (PET/CT) Study Using ⁸⁹Zr Df-IAB22M2C in Patients With Metastatic Melanoma Receiving Bempegaldesleukin (NKTR-214) and Nivolumab	NCT04955262		2019	2022	Interventional
‌ A Study of NKTR-358 (LY3471851) in Participants With Systemic Lupus Erythematosus (SLE)	NCT03556007	Systemic lupus erythematosus	April 18, 2018	August 29, 2019	Interventional
‌ A Single-Dose Study of LY3471851 in Healthy Participants	NCT04998487	‌ Healthy	August 16, 2021	July 6, 2022	Interventional
‌ NKTR-255 in Relapsed/Refractory Multiple Myeloma & Non-Hodgkin Lymphoma	NCT04136756	Non-Hodgkin lymphoma Multiple myeloma	October 7, 2019	April 24, 2023	Interventional
‌ A Single-Arm Study of Bempegaldesleukin (NKTR-214) Plus Nivolumab in Cisplatin Ineligible Patients Who Have Locally Advanced or Metastatic Urothelial Cancer	NCT03785925		April 29, 2019	June 30, 2022	Interventional
‌ A Phase 2 Study To Assess The Efficacy, Tolerability, And Safety OF NKTR-181 In Subjects With Chronic OA Knee Pain	NCT01619839		2012	2013	Interventional
‌ A Placebo Controlled Trial of Bempegaldesleukin (BEMPEG; NKTR-214) With Standard of Care in Patients With Mild COVID-19	NCT04646044	COVID-19	November 13, 2020	May 18, 2021	Interventional
‌ Efficacy and Safety Study of NKTR-181 in Opioid-Naive Subjects With Low Back Pain	NCT02362672	‌ Chronic pain Low back pain	March 11, 2015	2017	Interventional
‌ NKTR-102 Versus Irinotecan in Patients With Second-Line, Irinotecan-Naïve, KRAS Mutant, Colorectal Cancer	NCT00856375	Colorectal cancer	2008	2014	Interventional
‌ Long-Term Safety and Tolerability Study of NKTR-181 in Subjects With Chronic Low Back Pain or Chronic Non-Cancer Pain	NCT02367820	‌ Chronic pain Low back pain	April 14, 2015	2018	Interventional
‌ A Phase 1/2 Multicenter Dose Escalation and Expansion Study Of NKTR-214 In Subjects With Locally Advanced Or Metastatic Solid Tumors	NCT02869295		2015	October 31, 2018	Interventional
‌ NKTR-102 in Combination With Cetuximab in Patients With Refractory Solid Tumors (Phase 2a) and Metastatic or Locally Advanced Colorectal Cancer (Phase 2b)	NCT00598975	Colorectal cancer	2008	2011	Interventional
‌ A Study of Bempegaldesleukin (NKTR-214: BEMPEG) in Combination With Nivolumab Compared With the Investigator's Choice of a Tyrosine Kinase Inhibitor (TKI) Therapy (Either Sunitinib or Cabozantinib Monotherapy) for Advanced Metastatic Renal Cell Carcinoma (RCC)	NCT03729245	Renal cell carcinoma	December 18, 2018	October 19, 2022	Interventional
‌ A Dose Escalation and Cohort Expansion Study of NKTR-214 in Combination With Nivolumab and Other Anti-Cancer Therapies in Patients With Select Advanced Solid Tumors	NCT02983045	Renal cell carcinoma Melanoma	December 19, 2016	April 28, 2022	Interventional
‌ The BEACON Study (Breast Cancer Outcomes With NKTR-102)	NCT01492101	Metastatic breast cancer	2011	2016	Interventional
‌ Study to Evaluate the Safety and Efficacy of NKTR-102 in Patients With Metastatic or Locally Advanced Ovarian Cancer	NCT00806156	Ovarian cancer	2008	2013	Interventional
‌ An Extension Study of NKTR-102 in Cancer Patients Previously Enrolled in NKTR-102 Studies	NCT01457118		2011	2017	Interventional
‌ Study to Evaluate the Safety and Efficacy of NKTR-102 in Patients With Metastatic or Locally Advanced Breast Cancer	NCT00802945	‌ Breast Cancer	2008	2012	Interventional
‌ A Study of LY3471851 in Adults With Systemic Lupus Erythematosus (SLE)	NCT04433585	Systemic lupus erythematosus	August 19, 2020	February 16, 2023	Interventional
‌ Study to Compare Adjuvant Immunotherapy of Bempegaldesleukin Combined With Nivolumab Versus Nivolumab After Complete Resection of Melanoma in Patients at High Risk for Recurrence	NCT04410445	Melanoma	July 27, 2020	September 22, 2022	Interventional
‌ Bempegaldesleukin and Pembrolizumab With or Without Chemotherapy in Locally Advanced or Metastatic Solid Tumors	NCT03138889		June 9, 2017	August 24, 2022	Interventional
‌ A Study of LY3471851 in Healthy Participants	NCT04133116	‌ Healthy	October 29, 2019	March 6, 2020	Interventional
‌ A Study of LY3471851 in Adult Participants With Moderately to Severely Active Ulcerative Colitis (UC)	NCT04677179		March 22, 2021	August 9, 2022	Interventional