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Though it requires a living host to survive, the Venom symbiote is adept at fending for itself independent of a host. The symbiote is capable of shapeshifting abilities, including the ability to form spikes or expand its size,as well as mimic the appearance of other humanoids after it has obtained a host. The organism can additionally use its shape-shifting abilities to conceal itself by altering its coloration or by becoming completely invisible. It also contains a small "dimensional aperture", allowing its hosts to carry items without adding mass to the costume. The symbiote also exhibits telepathic abilities, primarily when it needs to communicate with its host.

Because of its contact with Spider-Man, the symbiote grants all of its subsequent hosts that hero's powers and cannot be detected by his spider-sense. As Spider-Man's fighting style is partly dependent on his spider-sense, his effectiveness was somewhat hampered when he battled Eddie Brock. Retaining its memory from the time it was bonded with Spider-Man, Venom is also capable of producing webbing similar to Spider-Man's variety created from its biomass.

The symbiote greatly enhances the physical strength of those it bonds with. Its hosts experience a vastly larger size and musculature. The symbiote displays non-human teeth, which are very sharp, and commonly protrude a long, prehensile tongue from its mouth. Venom is depicted as being physically much bigger than Spider-Man, as well as having more brute strength.

Venom exhibits some immunities to the supernatural powers of others such as the Penance Stare of Ghost Rider or Spider-Man's extrasensory spider-sense.

Some incarnations of the Venom symbiote have shown it able to replicate itself. This ability is shown in the 2005–2006 miniseries Spider-Man: Reign when Venom recreates his symbiote to combat his loneliness.

The Venom symbiote is vulnerable to fire and sonic waves, causing it great pain and exhaustion if it sustains enough exposure. It can sense and track all of its offspring symbiotes except Carnage, who learned how to block this ability shortly after bonding with Cletus Kasady and confronting Venom/Eddie Brock for the first time.

The Venom symbiote is shown to form giant web-like dragon wings when it was in contact with Knull.

Bioscience genius Dr. Bruce BannerBruce Banner focused his major studies on the effects of gamma radiation on humans, working alongside Dr. Betty Ross at a Virginia University lab. Dr. Ross’ father, General “Thunderbolt” Ross of the U.S. ArmyU.S. Army, channeled Banner’s work into a program to develop weapons for the military, unbeknownst to both doctors. When Banner decided to test what he learned on himself, he triggered a fantastic transformation in himself that resulted in an immense, hulking figure fueled by his own rage.

Having destroyed his lab as the creature, and inadvertently harming Ross in the process, Banner slipped away to avoid capture and study by the ArmyArmy and began a desperate quest for a cure to his bizarre affliction.

As intelligent and cerebral as Bruce Banner is, his alter-ego the Hulk is a completely physical phenomenon. The green behemoth possesses the greatest raw strength of any natural being on EarthEarth, with an upper limit that has yet to be fully tested. His leg muscles allow him to leap great distances and land without harm, and his skin can resist damage from heavy weaponry, as well as the natural elements and even unnatural ones.

Banner is considered one of the greatest scientific minds on Earth, possessing "a mind so brilliant it cannot be measured on any known intelligence test." Norman Osborn estimates that he is the fourth most-intelligent person on Earth. Banner holds expertise in biology, chemistry, engineering, medicine, physiology, and nuclear physics. Using this knowledge, he creates advanced technology dubbed "Bannertech", which is on par with technological development from Tony StarkTony Stark or Doctor DoomDoctor Doom. Some of these technologies include a force fieldforce field that can protect him from the attacks of Hulk-level entities, and a teleporte teleporter.

The Hulk possesses the potential for seemingly limitless physical strength which is influenced by his emotional state, particularly his anger. This has been reflected in the repeated comment, "The madder Hulk gets, the stronger Hulk gets." The cosmically-powerful entity known as the Beyonder once analyzed the Hulk's physiology, and claimed that the Hulk's potential strength had "no finite element inside."Hulk's strength has been depicted as sometimes limited by Banner's subconscious influence; when Jean GreyJean Grey psionically "shut Banner off", Hulk became strong enough to overpower and destroy the physical form of the villain Onslaught. Writer Greg Pak described the Worldbreaker Hulk shown during World War Hulk as having a level of physical power where "Hulk was stronger than any mortal—and most immortals—who ever walked the Earth" and depicted the character as powerful enough to completely destroy entire planets. His strength allows him to leap into lower Earth orbit or across continents,and he has displayed superhuman speed. Exposure to radiation has also been shown to make the Hulk stronger.It is unknown how he gains biomass during transformation but it may be linked to the One-Below-All.

He also possesses less commonly described powers, including abilities allowing him to "home in" to his place of origin in New Mexico; resist psychic controlpsychic control, or unwilling transformatiounwilling transformation; grow stronger from radiation or dark magic; punch his way between separate temporal or spatial dimensions; and to see and interact with astral forms.Some of these abilities were in later years explained as being related; his ability to home in on the New Mexico bomb site was due to his latent ability to sense astral forms and spirits, since the bomb site was also the place where the Maestro's skeleton was and the Maestro's spirit was calling out to him in order to absorb his radiation.