Daniel Frumkin

H2nanO is a company that is innovating nanotechnology solutions in order to face environmental challenges. The company was founded in 2015 in Kitchener, Ontario, Canada.

Destroying and eliminating difficult to eradicate contaminants that may exist in industrial wastewater is what H2nanO has centered their systems around. The treatments H2nanO's technology applies allows for water to be reusable and to catalyze to specific treatment chemicals, which mineralizes contaminants and thereby purifying the water.

Using an approach known as an advanced oxidation process treatment, they are able to recover and reuse nano-engineered catalysts that are introduced to the water. These nano catalysts are used to destroy hard-to-degrade dissolved organics such as petrochemicals, surfactants, solvents, dyes, polymers, as well as recalcitrant organics. Pharmaceuticals, pesticides, various forms of industrial waste, and endocrine disruptors also perish through this process. The steps that are included in the process are discharging and destroying toxins, enabling economical efficieny to increase for municipal and industrial processing, and remediation, or, cleaning the site.

Humai Technologies is a company that offers a platform that identifies what spare parts are necessary for a repair or installation. The company was founded in 1998, in Vienna, Italy.

Humai Technologies' platform utilizes metric learning, automated segmentation, sizing, active learning, and metadata artificial intelligence in order to filter parts, confirm what is correct and not, and achieve high recognition rates. The platform is able to find parts for industrial, manufacturing, automotive, and retail industries. The Partium Paradigm is the platform that Humai Technologies has implemented to help customers and users find parts that they need.

Relying on more than computer vision to recognize parts, Partium also utilizes artificial intelligence in order filter parts that are based on various criteria. Their artificial intelligence technology, called Delta, augments the metadata associated with parts in order to search and filter for the correct piece. Location, assembly base, and sometimes other follow-up questions are used to search upon.

Avails Medical is a company that develops technologies that are able to detect infections. The company was founded by Meike Herget, Naama Stauber Breckler, Nancy Isaac, Oren Knopfmacher, and Robert Fisher in 2013, in San Francisco, California, United States.

Using bodily fluid to detect infections and indicate in real-time which treatments and drugs will be the most effective. Changing how diagnostics are provided to patients in order to reduce the time it takes for them to get treatments is what their platform has been designed for.

The platform is centered around a digital sensor technology that provides in-vitro diagnostic processes in one device. The device provides data regarding the microorganism metabolism which allows users to read in real-time the pathogen quantification and AST in human specimens.

Patients and users are introduced to a process that includes testing for a positive blood culture, allowing the platform to rapidly identify specific organisms from the PBC from which a subculture is created. Then antibiotic susceptibility testing can be introduced to the process if equipment is at disposal. Finally a therapy or treatments can be administered to the patient.

Sylvatex is a company that is developing alternative options for fuels, materials, and industrial processes by means of a renewable nano-chemistry platform. The company was founded by Virginia Klausmeier in 2012, in San Francisco, California, United States.

Chemicals, fabricate materials or structures are manipulated by the biomaterial-based nano-particles that Sylvatex has created. In order to fabricate nano-particles, Sylvatex implements their IP-protected platform, and their database that spans across industries such as batteries, materials, fragrances, fuels, and industrial settings. All of their products are manufactured from locally sourced renewable components.

With the combination of their platform and their proprietary nano-particle system, they are able to manipulate how water and oil interact in components as well as the applications of of nano-scale materials such as delivery mechanisms for oxygenates. Using biomass-derived inputs, the platform allows for self-assembly to take place by thermodynamic stable liquid crystal micro-emulsion. In turn, the compound is then composed of inverse micelles in the interior of a bubble, which allows for a renewable combustible sufactant.

Transaction validation is the process of determining if a transaction conforms to specific rules to deem it as valid. Validators (also called miners) check if transactions meet protocol requirements before adding the transactions to the distributed ledger as part of the validating process.

In decentralized networks, economic incentives are used to encourage validators to follow protocol rules. For example, a Bitcoin validator who is honest and follows the protocol rules will have a chance to earn revenue in the form of block rewards and transaction fees. On the other hand, a dishonest validator who attempts to add invalid transactions that don't meet protocol requirements to the blockchain will not earn any revenue unless a majority of the other validators are also dishonest.

This validation process is carried out by nodes who store full copies of the blockchain. When nodes validate a transaction, it is added to the mempool (short for memory pool). In a proof of work network, miners are incentivized by transaction fees to confirm these transactions by including them in a block in the blockchain, establishing a clear chronological record of when the transaction occurred so that a later transaction cannot spend the same coins as in the original.

Innova Dynamics is a company known for creating electronic materials for touch screen and display purposes. The company was founded by Alex Mittal, Arjun Srinivas, and Michael Young in 2007, in San Francisco, California, United States.

Commercializing materials that can transform polymers, surfaces, and devices by embedding nanoparticles into the surface of items is Innova's primary strategy. The application products they offer form transparent conductive electrodes for touch sensor devices. They manufacture and develop surfaces for antimicrobials, catalysis, decorations, optical management, thermo-mechanical performance, and other applications.

The materials that Innova manufactures are applied using a wet deposition process called roll-to-roll coating on conductive films, or through screen printing. Their platform, Innlay, allows the deposition method to provide a low-viscosity carrier for the particles across a surface. Once the particles are applied to the surface of a wet film they form a two-dimensional network. The solvents the swell or dissolve, and the polymer mesh structure is retained as nanoparticles are embedded to the surface. As the solvents dry, the polymers are embedded into the particles. These methods are utilized on touch screen phones, tablets, and ultrabooks.

Mekonos is a company that has created a platform that allows cell and gene therapies to be more accessible. The company was founded by Anil Narsimha, Greg Sitters, and Steven Banerjee in 2017, in San Francisco, California, United States.

Mekonos is responsible for developing over nine hundred therapeutic candidates, and expect roughly forty of them to be approved by the end of 2022. They developed their therapeutics through their platform solution, Iris, which is a System-on-a-Chip that allows for automated deliveries and precision for multiplexing.

Iris is a pharmaceutical and biotechnological platform that allows for targeted delivery and dose control of gene therapeutics that includes nucleic acids, protein complexes, and small molecules, and cell treatments such as primary, immune, and stem cells.

Microfluidics, micro-electro-mechanical systems, and chemistry to expand their catalogue of payloads and cell types. Their various methods of expansion allows Mekonos to scale their silicon technology for drug discover and development.

Vaylenx is a company that specializes in developing biotechnology vector control methods and solutions. The company was founded in 2015, in Washington, District of Columbia, United States.

Their solutions have been designed to fight against and repel mosquitoes and other insect pests, as well as vector borne diseases. Fighting against mosquito-spread diseases and slowing the widespread effects of them through ecological chemical products is the strategy of Vaylenx.

KeriCure is a company that develops novel biotechnology products that are designed specifically for skin and wound care. The company was founded in 2014, in Tampa, Florida, United States.

Their nanopolymer technologies and products are designed to remove and keep bacteria outside of wounds and off the skin while moisturizing the user's skin. Without using harsh chemicals, additives, antibiotics, or solvents, their spray products allow patients to avoid reactions or irritation.

The wound dressings that they have developed are applied through a spray on application. The United States military uses the nanopolymer spray for their soldiers to attend to wounds in difficult conditions and harsh environments. The spray can also be used to heal laser ablations that come from removing facial moles, to moisturize and sooth skin irritations, and to hydrate the skin on a basic level.

KeriCure offers over twenty-five different skin care and wound care products, as well as personal protective equipment, and sanitizers. All of the nanopolymers offered by the company are hypoallergenic as they are all inert polymers that don't degrade or breakdown.

MicroGen Systems is a company that provides research and development, systems design, and application commercialization for systems that involve Internet of Things. The company was founded in 2007, in West Henrietta, New York, United States.

MicroGen Systems was acquired by Wireless Sensor Solutions.

Nanomix is a company that is known for creating healthcare options for patients that can provide them with rapid and portable diagnostic systems. The company was founded in 2000 by Marvin L. Cohen and Alex Zettl, in Emeryville, California, United States.

The company offers their solutions in order to assist in the treatment and testing of COVID-19. The immunoassay approach Nanomix provides was designed to be handheld, provide rapid results with quantitative information, allowing for a mobile approach to testing diagnostics. Interactions between patients and healthcare professionals is possible at the hospital, via telecommunications, or through alternative point of care solutions with Nanomix.

Nanomix has developed their technologies in order to decentralize disease diagnostics. The assay diagnoses acute kidney injuries, SARS-CoV-2 antigens and antibody tests, cardiac issues, strokes, and traumatic brain injuries. Decentralizing the diagnosis process allows healthcare providers to offer direct and rapid information to their patients.

Carbice is a company that produces and develops materials for electronics or industrial products. The company was founded in 2017, in Atlanta, Georgia, United States.

Producing materials that have multiple purposes and functions in terms of performance, reliability, and cost effectiveness is what Carbice offers with their proprietary solution, Carbice Carbon. Carbice Carbon is a material product that is designed to maintain electronic temperatures at a cooler temperature, be resilient in harsh conditions, and provide its properties for a long period of time.

The Carbon product is available in three main series including their TI Series, TS Series, and TB Series, however extra features can be added to any of these products. The TI Series is designed for extreme conditions on Earth. TS Series is meant to be applied to items and materials that are used in space. The TB Series is meant for basic applications. Each of these series can be equipped with extra characteristics including a conductive adhesive, built-in electrical grounding, custom solutions, and can be sized to a customer's requirements.

T2 Biosystems is a company that is known for developing products that treat life altering diseases. The solutions that they have developed were created with the purpose of saving lives and reducing the healthcare costs for patients and caregivers.

Some of the products and solutions that T2 Biosystems has developed includes their T2 Biosystems, T2MR, T2Bacteria Panel, T2Candida Panel, and T2Dx. They are also developing their T2Direct Diagnostics, T2HemoStat, T2Plex, T2Cauris, T2Resistance, and T2SARS-CoV-2 in their pipeline.

Innovating solutions to treat against diseases such as sepsis, hemostasis, and bacterial and Lyme disease is possible through the company's T2MR method. T2MR is a method that utilizes miniaturized magnetic resonance technology to measure the reaction of water molecules that are present around a magnetic field. The method does not require purification or extraction of target molecules in order to identify those target molecules.

The number of cells that is required for the T2MR to detect target cells or organism in a blood culture can be as low as 1 CFU/mL, as opposed to the standard range of 10,000 to 1,000,000 CFUs/mL. This property of the method allows the T2MR to detect low levels of pathogens in whole blood.

QD Vision is a company that is known for developing and providing display and lighting solutions for commercial products. The company was founded by Greg Moeller, Jonathan S. Steckel, and Seth Coe-Sullivan in 2004, in Lexington, Massachusetts, United States.

QD Vision was acquired by Samsung Electronics.

ViaeX is a company that develops nano-filtration systems for water and air that target pollutants and bacteria that may be present in an environment. The company was founded by Hudson Liao, Rui Wang, and Vivian Qu in 2016, in San Francisco, California, United States.

The filtration systems that ViaeX is responsible for are made from biodegradable chitosan bio waste, renewable materials. They can be used in industries such as water purification, industrial separation, skin care, food and beverage filtration, healthcare, and wound treatments.

Membranes in the chitosan are processed by electro-spinning into the nano fibrous surface areas, allowing for lower contaminant amounts. The process that customers and users navigate to select what they need includes selecting materials, profiling a target material design, making a target system design, pre-processing the designs, synthesizing and characterizing the material, post-processing the material, prototyping, and finally scaling.

The bio-waste that is used as a base material was chosen to reduce the amount of natural resources that are used in industrial processes and in various industries.

Oxford PV Limited is a company that offers solutions and technologies that are meant to innovate perovskite solar cells. The company was founded in 2010 in Oxford, Oxfordshire, United Kingdom.

The photovoltaic technologies that Oxford PV utilizes are meant to compliment standard silicon solar cells and are designed to improve standard solar cells. Their solar cells are installed with silicon heterojunction solar cell lines which is designed to enhance production equipment of the perovskite top cell.

Oxford PV maintains their mission to enhance photovaltaic silicon solar cells, and bring the efficiency limit from 29% to 43% for these cells. Their technology is able to capture specific parts of the solar spectrum, mostly within the high-energy blue side. The materials that their solar cells are made from are generally low cost source materials.

The company is partnered with the European Investment Bank, Oxford University Innovation, University of Oxford, Legal&General, equinor, Meyer Burger, and Goldwind.

Liquidia Technologies is a company that maintains the mission of developing and changing how drugs and therapies are engineered. The company was founded in 2004, in Morrisville, North Carolina, United States.

The company has developed a proprietary technology named PRINT, which allows users to solve problems they may face in drug delivery and efficacy. The technology hold a scalable cGMP process that creates particle that can be applied to any therapeutic or point of administration.

PRINT allows for particle engineering platforms to provide control over drug particle size, shape, and chemical composition. This allows their users to selectively create their desired pharmacological effects such as time of drug release, amount of drug loading, route of administration, and novel storage and combination of products.

The platform allows for particle molding and allows users to deliver scalable processes that meet cGMP requirements. The technology is also a solution for semi-conductor markets as PRINT allows for the manufacturing of uniform particles at a commercially viable scale.

NBD Nanotechnologies is a company that is able to provide coatings and additives that change the wetting properties of a surface. The company was founded by Deckard Sorensen and Miguel Galvez in 2012, in Boston, Massachusetts, United States.

The company has developed coatings that offer antimicrobial protection, soft-touch textures, scratch and abrasion resistance, dirt and stain resistance, and fingerprint hiding properties. Their solutions are available as coatings, additives, and adhesions promoters.

Coatings provide transparency and repellency to be resilient in harsh conditions and environments. Additives can be applied to materials from the inside out, and adhesion promoters allow for their coatings to maintain a longer life span.

The antimicrobial coatings that NBD Nanotechnologies offers are transparent, can be applied to leather, plastics, and UV cured materials, are offered in soft or hard coating formulations, and don't contain Flourine.

Selecta Biosciences is a bio-pharmaceutical company that is known for developing therapies and treatments for unwanted immune responses. The company was founded by Omid Farokhzad in 2008, in Watertown, Massachusetts, United States.

Creating a generation of nanoparticle immunomodulatory drugs that can treat or prevent certain diseases by restoring the body's natural tolerances to autoimmune diseases, and inducing tolerance to highly immunogenic proteins is what their therapeutic programs are designed for. Their program, ImmTOR, is both a gene and gout therapy program. With gout, ImmTOR is meant to be co-administered with the company's proprietary uricase named pegadricase in order to power efficacy in chronic refractory gout.

The program can also be used to mitigate the immunogenicity to AAV gene therapies and re-dose gene therapy. Boosting and maintaining transgene expression over time for patients that had genetic metabolic diseases since childhood is one of the purposes for ImmTOR. The AAV gene therapy is introduced to the dendritic cell, which sends a guided message to a naive T-cell. This can split into a helper T-cell or a B-cell, and both repeat AAV gene therapy efficacy.

Sirnaomics is a company that is known for developing clinical-stage bio-pharmaceuticals and therapeutics for life-threatening diseases. The company was founded by Patrick Y. Lu in 2007, in Washington DC, Virginia, United States.

The focus of Sirnaomics is to created RNAi therapuetics that are able to treat critical diseases such as cancer or fibrosis diseases. Developing novel siRNA-based therapeutics through their proprietary algorithm for sequencing predictions allows them to treat against specific gene targets and identify siRNAs for use against non-drugable targets.

Treatments that Sirnaomics has created and are within their pipeline include therapeutics for oncology, anti-fibrosis, anti-viral, and galahead diseases. For oncology, treating non-melanoma skin cancer, liver cancer, bladder cancer, liver cancer, colon cancer, breast cancer, and multiple cancers remain their primary focus. Hypertrophic scar reduction, keloid scarless healing, liver fibrosis (both PSC and NASH), and lung fibrosis all have anti-fibrosis solutions or treaments under development. The viral diseases the company is compiling a solution for include influenza and the coronavirus. For galahead diseases, they are finding treatments for anticoagulant therapy, dyslipidemia and metabolic disease, as well as liver fibrosis.