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US Patent 9828363 Fused pyrimidines as inhibitors of P97 complex

Patent 9828363 was granted and assigned to Cleave Biosciences, Inc. on November, 2017 by the United States Patent and Trademark Office.

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Patent Applicant
Cleave Biosciences, Inc.
Cleave Biosciences, Inc.
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Current Assignee
Cleave Biosciences, Inc.
Cleave Biosciences, Inc.
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
98283630
Patent Inventor Names
Han-Jie Zhou0
David Wustrow0
Date of Patent
November 28, 2017
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Patent Application Number
151126590
Date Filed
January 19, 2015
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Patent Primary Examiner
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Bruck Kifle
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Patent abstract

The present invention is directed to certain fused pyrimidines having a homo or hetero cyclopentyl, cyclohexyl or cycloheptyl ring as the pyrimidine fusion partner; having an amino benzyl or substituted amino benzyl group at the 4 position of the pyrimidine ring; and a 5:6 heterobicyclo ring with at least one N, O or S at the 2 position of the pyrimidine ring. These compounds are useful for treatment of cancer by inhibition of the p97 complex.

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