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US Patent 9572879 ROBO2 inhibitory compositions comprising SLIT2-binding extracellular domain of ROBO2

Patent 9572879 was granted and assigned to Boston Medical Center on February, 2017 by the United States Patent and Trademark Office.

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Patent
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Patent attributes

Patent Applicant
Boston Medical Center
Boston Medical Center
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Current Assignee
Boston Medical Center
Boston Medical Center
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
95728790
Patent Inventor Names
David J. Salant0
Weining Lu0
Xueping Fan0
Date of Patent
February 21, 2017
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Patent Application Number
143690940
Date Filed
January 4, 2013
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Patent Citations Received
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US Patent 11970524 Recombinant ROBO2 proteins, compositions, methods and uses thereof
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Patent Primary Examiner
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Zachary Howard
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Patent abstract

Provided herein are methods for the treatment of chronic kidney disease and proteinuria and for the diagnosis of chronic kidney disease and monitoring the effects of treatment on the progression of chronic kidney disease and proteinuria based on unexpected roles for the SLIT-ROBO signaling pathway in the regulation of podocyte F-actin cytoskeleton and foot process structure in the kidney.

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