Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Steven C.J. Geysens0
Nico L.M. Callewaert0
Roland Contreras0
Date of Patent
June 7, 2016
0Patent Application Number
141523290
Date Filed
January 10, 2014
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides genetically engineered strains of Pichia capable of producing proteins with reduced glycosylation. In particular, the genetically engineered strains of the present invention are capable of expressing either or both of an α-1,2-mannosidase and glucosidase II. The genetically engineered strains of the present invention can be further modified such that the OCH1 gene is disrupted. Methods of producing glycoproteins with reduced glycosylation using such genetically engineered stains of Pichia are also provided.
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