Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Timothy B. Lowinger0
Mao Yin0
Natalya D. Bodyak0
Patrick R. Conlon0
Aleksandr Yurkovetskiy0
Charles E. Hammond0
Cheri A. Stevenson0
Dmitry R. Gumerov0
...
Date of Patent
February 9, 2016
0Patent Application Number
144579550
Date Filed
August 12, 2014
0Patent Primary Examiner
Patent abstract
Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently an Auristatin compound. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.
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