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US Patent 9175289 Reduced size self-delivering RNAi compounds

Patent 9175289 was granted and assigned to Rxi Pharmaceuticals Corporation on November, 2015 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Patent Applicant
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Rxi Pharmaceuticals Corporation
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Current Assignee
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Rxi Pharmaceuticals Corporation
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
91752890
Date of Patent
November 3, 2015
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Patent Application Number
142789000
Date Filed
May 15, 2014
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Patent Citations Received
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US Patent 12104156 Compositions and methods of treating facioscapulohumeral muscular dystrophy
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US Patent 12077755 Bioactive conjugates for oligonucleotide delivery
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US Patent 11702659 Optimized anti-FLT1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
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US Patent 11712478 Compositions and methods of treating muscle atrophy and myotonic dystrophy
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US Patent 11753638 Conjugated oligonucleotides
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US Patent 11767527 Modified oligonucleotides targeting SNPs
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Patent Primary Examiner
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Jennifer McDonald
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Patent abstract

The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing.

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