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US Patent 7045353 Directed differentiation of human embryonic cells

Patent 7045353 was granted and assigned to Yissum on May, 2006 by the United States Patent and Trademark Office.

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Current Assignee
Yissum
Yissum
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
70453530
Patent Inventor Names
Nissim Benvenisty0
Date of Patent
May 16, 2006
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Patent Application Number
099187020
Date Filed
July 31, 2001
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Patent Citations Received
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US Patent 11835433 Non-invasive, in vitro functional tissue assay systems
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Patent Primary Examiner
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Deborah Crouch
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Patent abstract

Methods are described for mapping a pathway of differentiation of a population of embryonic cells which includes exposing the cells to an exogenous factor and measuring gene expression products that are characteristic of a particular cell type or lineage. Directing differentiation of human embryonic cells relies on dissociated embryoid bodies which are then exposed to one or more exogenous factors to enrich a culture for a particular cell type. The differentiated cells may be used for treating a medical condition in a human. Kits for determining differentiation pathways and screening exogenous factors for their utility in differentiation are provided.

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