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US Patent 12129300 Antibody variable domains targeting the NKG2D receptor

Patent 12129300 was granted and assigned to Dragonfly Therapeutics, Inc. on October, 2024 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

Dragonfly Therapeutics, Inc.

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Current Assignee

Dragonfly Therapeutics, Inc.

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Bradley M. Lunde0

Ann F. Cheung0

Asya Grinberg0

Bianka Prinz0

Gregory P. Chang0

William Haney0

Date of Patent

October 29, 2024

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Patent Application Number

185014190

Date Filed

November 3, 2023

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Patent Citations

US Patent 7695936 Knobs and holes heteromeric polypeptides

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US Patent 7820166 Potent T cell modulating molecules

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US Patent 7879985 Antibodies against human NKG2D and uses thereof

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US Patent 7112324 CD 19×CD3 specific polypeptides and uses thereof

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US Patent 7235641 Bispecific antibodies

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US Patent 7575923 CD19xCD3 specific polypeptides and uses thereof

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US Patent 7635472 Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders

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US Patent 7642228 Method for making heteromultimeric polypeptides

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Patent Primary Examiner

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Patent abstract

Antibody heavy chain variable domains that can be paired with antibody light chain variable domains to form an antigen-binding site targeting the NKG2D receptor on natural killer cells are described. Proteins comprising an NKG2D antigen-binding site, pharmaceutical compositions and therapeutic methods thereof, including for the treatment of cancer, are also described.

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