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US Patent 12103954 Heterodimeric Fc cytokines and uses thereof

Patent 12103954 was granted and assigned to Synthekine on October, 2024 by the United States Patent and Trademark Office.

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Is a
Patent
Patent
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Patent attributes

Patent Applicant
Synthekine
Synthekine
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Current Assignee
Synthekine
Synthekine
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
121039540
Patent Inventor Names
Patrick Lupardus0
Deepti Rokkam0
Date of Patent
October 1, 2024
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Patent Application Number
185821800
Date Filed
February 20, 2024
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Patent Citations
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US Patent 7576193 Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation
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US Patent 7872107 Interleukin-12p40 variants with improved stability
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US Patent 7879319 Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation
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US Patent 7915025 In vivo incorporation of unnatural amino acids
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US Patent 7943743 Human monoclonal antibodies to programmed death ligand 1 (PD-L1)
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US Patent 8008449 Human monoclonal antibodies to programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
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US Patent 8168757 PD-1 binding proteins
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US Patent 8217149 Anti-PD-L1 antibodies, compositions and articles of manufacture
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...
Patent Primary Examiner
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Sudhakar Katakam
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Patent abstract

The present disclosure provides IL12 and IL23 muteins as partial agonists comprising modified human p40 molecules that associate with human p35 (hP35) and human P19 (hP19) to form modified hIL-12 and IL23 partial agonists wherein the individual components of IL12 and IL23 muteins are linked to engineered Fc domains.

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