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Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Frank DeRosa0
Anusha Dias0
Michael Heartlein0
Shrirang Karve0
Date of Patent
August 13, 2024
0Patent Application Number
178110290
Date Filed
July 6, 2022
0Patent Citations
...
Patent Primary Examiner
CPC Code
Patent abstract
The present invention provides, among other things, methods of purifying messenger RNA (mRNA) including the steps of (a) precipitating mRNA from an impure preparation; (b) subjecting the impure preparation comprising precipitated mRNA to a purification process involving membrane filtration such that the precipitated mRNA is captured by a membrane; and (c) eluting the captured precipitated mRNA from the membrane by re-solubilizing the mRNA, thereby resulting in a purified mRNA solution. In some embodiments, a purification process involving membrane filtration suitable for the present invention is tangential flow filtration.
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