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US Patent 11786578 Modified relaxin polypeptides and their uses

Patent 11786578 was granted and assigned to Ambrx on October, 2023 by the United States Patent and Trademark Office.

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Contents

Is a
Patent
Patent

Patent attributes

Patent Applicant
Ambrx
Ambrx
Current Assignee
Ambrx
Ambrx
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
11786578
Patent Inventor Names
Lorraine Sullivan
Jason Pinkstaff
Vadim Kraynov
Kristine De Dios
Amha Hewet
Nick Knudsen
Date of Patent
October 17, 2023
Patent Application Number
17685658
Date Filed
March 3, 2022
Patent Citations
‌
US Patent 7638299 Biosynthetic polypeptides utilizing non-naturally encoded amino acids
‌
US Patent 7638491 Therapies using non-natural amino acids and polypeptides
‌
US Patent 7696312 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
‌
US Patent 7736872 Compositions of aminoacyl-TRNA synthetase and uses thereof
‌
US Patent 7737226 Acetylene group-containing poly(alkylene oxide, oxyethylated polyol or olefinic alcohol)
‌
US Patent 7816320 Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35
‌
US Patent 7820766 Branched acetylene-containing poly(alkylene oxides, oxyethylated polyols or olefinic alcohols)
‌
US Patent 7829310 Compositions of aminoacyl-tRNA synthetase and uses thereof
...
Patent Primary Examiner
‌
Christine J. Saoud
Patent abstract

Modified relaxin polypeptides and their uses thereof are provided. Exemplary embodiments provide relaxin polypeptides which include one or more amino acid substitutions with natural or non-naturally encoded amino acids, and/or linkage to a water-soluble polymer, such as polyethylene glycol. Additionally, use of said relaxin polypeptides for treatment of disease, such as heart failure, is also provided.

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