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US Patent 11654105 Subcutaneous HER2 antibody formulations

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Date of Patent

May 23, 2023

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Patent Application Number

178214260

Date Filed

August 22, 2022

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Patent Citations

US Patent 7700299 Method for predicting the response to a treatment

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US Patent 8840896 Anti-HER2 antibody variants

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US Patent 9017671 Method of treating cancer with a pharmaceutical formulation comprising a HER2 antibody

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US Patent 9107926 Mutant selectivity and combinations of a phosphoinositide 3-kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer

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US Patent 9249218 Protein purification

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US Patent 9345661 Subcutaneous anti-HER2 antibody formulations and uses thereof

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US Patent 9551033 Gene expression markers of tumor resistance to HER2 inhibitor treatment

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US Patent 9687568 Composition of a first non-labeled monoclonal antibody binding to a tumor antigen and a non-cross reactive second monoclonal antibody labeled with a NIR fluorescence label

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Patent Citations Received

US Patent 11992529 Adjuvant treatment of HER2-positive breast cancer

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US Patent 12110341 Composition comprising antibody that binds to domain II of HER2 and acidic variants thereof

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US Patent 12128103 Adjuvant treatment of HER2-positive breast cancer

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Patent Primary Examiner

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CPC Code

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Fixed dose HER2 antibody formulations for subcutaneous administration are provided along with their use in the treatment of cancer. The formulations include fixed dose subcutaneous formulations of pertuzumab and subcutaneous co-formulations of pertuzumab and trastuzumab, and their use in the treatment of cancer.

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