Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Zhenhua Wu0
Thiwanka Samarakoon0
Xiang Liu0
Yonghong Xiao0
Andrew Cook0
Dominic Reynolds0
Ermira Pazolli0
James Palacino0
...
Date of Patent
June 7, 2022
Patent Application Number
17247117
Date Filed
November 30, 2020
Patent Primary Examiner
Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.
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