Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
James T. Koerber0
Leah C. T. Byrne0
John G. Flannery0
Ryan R. Klimczak0
Meike Visel0
David V. Schaffer0
Deniz Dalkara Mourot0
Date of Patent
February 1, 2022
0Patent Application Number
162300800
Date Filed
December 21, 2018
0Patent Citations
Patent Primary Examiner
Patent abstract
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via intravitreal injection, compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
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