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US Patent 10561732 Trialkyl cationic lipids and methods of use thereof

Patent 10561732 was granted and assigned to Arbutus Biopharma Corporation on February, 2020 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Patent Applicant
Arbutus Biopharma Corporation
Arbutus Biopharma Corporation
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Current Assignee
Arbutus Biopharma Corporation
Arbutus Biopharma Corporation
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
105617320
Patent Inventor Names
Alan Martin0
James Heyes0
Mark Wood0
Date of Patent
February 18, 2020
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Patent Application Number
151500160
Date Filed
May 9, 2016
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Patent Citations Received
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US Patent 11980673 Compositions and systems comprising transfection-competent vesicles free of organic-solvents and detergents and methods related thereto
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US Patent 11395854 Trialkyl cationic lipids and methods of use thereof
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US Patent 11865190 Compositions and systems comprising transfection-competent vesicles free of organic-solvents and detergents and methods related thereto
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Patent Primary Examiner
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Sue X Liu
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Patent abstract

The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel, trialkyl, cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses.

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