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US Patent 10478494 FGFR/PD-1 combination therapy for the treatment of cancer

Patent 10478494 was granted and assigned to Astex Therapeutics Limited on November, 2019 by the United States Patent and Trademark Office.

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Contents

Is a
Patent
Patent
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Patent attributes

Patent Applicant
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Astex Therapeutics Limited
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Current Assignee
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Astex Therapeutics Limited
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
104784940
Patent Inventor Names
Matthew V. Lorenzi0
Jayaprakash Karkera0
Suso Jesus Platero0
Raluca Verona0
Date of Patent
November 19, 2019
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Patent Application Number
150791360
Date Filed
March 24, 2016
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Patent Citations
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US Patent 10052320 Substituted quinoxalines as FGFR kinase inhibitors
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US Patent 10039759 Quinolines as FGFR kinase modulators
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US Patent 10045982 Substituted pyrido[2,3-b]pyrazines as FGFR kinase inhibitors
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US Patent 10085982 Combinations
Patent Citations Received
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US Patent 11918576 Combination of an FGFR inhibitor and a CMET inhibitor
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US Patent 10716787 Combinations
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US Patent 10736900 Combinations of an FGFR inhibitor and an IGF1R inhibitor
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US Patent 10898482 Pharmaceutical compositions comprising N-(3,5-dimethoxyphenyl)-N'-1 methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine
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US Patent 11684620 Pharmaceutical compositions comprising N-(3,5-dimethoxyphenyl)-N′-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine
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Patent Primary Examiner
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Peter J Reddig
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Patent abstract

Provided herein are combination therapies for the treatment of cancer. In particular, the disclosed methods are directed to treatment of cancer in a patient comprising administering an antibody that blocks the interaction between PD-1 and PD-L1 and an FGFR inhibitor, wherein the antibody that blocks the interaction between PD-1 and PD-L1 and the FGFR inhibitor are administered if one or more FGFR variants are present in a biological sample from the patient.

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