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US Patent 10227576 Engineered cascade components and cascade complexes

Patent 10227576 was granted and assigned to Caribou Biosciences on March, 2019 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Patent Applicant
Caribou Biosciences
Caribou Biosciences
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Current Assignee
Caribou Biosciences
Caribou Biosciences
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
102275760
Patent Inventor Names
Samuel Henry Stemberg0
Sanne Eveline Klompe0
Peter Sean Cameron0
Date of Patent
March 12, 2019
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Patent Application Number
161048750
Date Filed
August 17, 2018
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Patent Citations Received
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US Patent 12084676 Cas9 orthologs
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US Patent 11512297 Affinity tag for recombination protein recruitment
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US Patent 11408012 Nucleic acid-guided nucleases
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US Patent 11407994 Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells via viral delivery
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US Patent 11884924 Dual strand nucleic acid-guided nickase editing
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US Patent 11891609 Methods for increasing observed editing in bacteria
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US Patent 11965186 Nucleic acid-guided nickases
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US Patent 11473214 Automated instrumentation for production of T-cell receptor peptide libraries
...
Patent Primary Examiner
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Catherine S Hibbert
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Patent abstract

The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides. Also, disclosed are methods for making and using the engineered Class 1 Type I CRISPR-Cas systems of the present invention.

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